The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 21, 1993
Filed:
Jul. 23, 1992
Kouhei Furuya, Hiromachi, JP;
Takao Okazaki, Hiromachi, JP;
Yoshio Tsujita, Hiromachi, JP;
Seigo Iwado, Hiromachi, JP;
Kiyoshi Hamano, Hiromachi, JP;
Masao Kuroda, Hiromachi, JP;
Jun Yoshikawa, Hiromachi, JP;
Toshiaki Iwai, Hiromachi, JP;
Kunio Nakano, Hiromachi, JP;
Sankyo Company, Limited, Tokyo, JP;
Abstract
Derivatives of ML-236B carboxylic acid, its salts and esters and corresponding lactone have a hydroxy group at the 3'-position and optionally also at the 6'-position. These derivatives may be prepared by the enzymatic hydroxylation of a corresponding ML-236B compound employing an enzyme produced by a microorganism of the genus Streptomyces or Amycolata, especially Streptomyces sp. SANK 62285, Streptomyces sp. SANK 62385, Streptomyces sp. SANK 62485, Streptomyces sp. SANK 62585, Amycolata autotrophica SANK 62781. Amycolata autotrophica subsp. canberrica SANK 62882 or Amycolata autotrophica subsp. amethystina SANK 62981. These derivatives have the ability to inhibit cholesterol biosynthesis.