The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 07, 1993

Filed:

Aug. 02, 1991
Applicant:
Inventors:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P / ; C12P / ; C12N / ;
U.S. Cl.
CPC ...
435 43 ; 435 44 ; 435 45 ; 435 46 ; 435 47 ; 435 49 ; 435117 ; 435118 ; 435176 ; 435177 ; 435178 ; 435179 ; 435180 ; 435228 ; 435229 ; 435230 ;
Abstract

Synthesis of semi-synthetic monobactamic or .beta.-Lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a thermodynamically controlled strategy in monophase water/cosolvent organic apolar systems, wherein the concentration of the cosolvent varies between 30% and 90%, the temperature between -10.degree. C. and 50.degree. C., the pH between 4.5 and 8.5, with concentrations of the antibiotic nucleus between 0.5 an 875 mM and acyl donor between 0.2 mM and 1M, with a relationship antibiotic ring/activated or free acyl donor, using a buffer between 0 and 1M. Application to the pharmaceutical industry.


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Guisan Seijas, Jose. (1993). Method for the synthesis of semi-synthetic antibiotics in (U.S. Patent No. 5268271). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5268271

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