The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 1993
Filed:
Aug. 05, 1992
Kernforschungsanlage Juelich GmbH, Juelich, DE;
Abstract
The selective determination of .alpha.-ketoisocaproate in samples of body fluids, especially in serum, is achieved, without previous separation, directly in the fluid and in the presence of NADH, by means of a KIC-specific D-.alpha.-hydroxy-isocaproic dehydrogenase that originates specifically from strains of Lactobacillus casei producing this enzyme, in particular strains of Lactobacillus casei subspecies pseudoplantarum or casei. The KIC determination is used, in particular, for diagnosing maple syrup urine disease. Expedient for this purpose are analytical kits which have a divisible stock of D-.alpha.-hydroxyisocaproic dehydrogenase from Lactobacillus casei, in particular from the Lactobacillus casei (DSM 20008).