The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 02, 1993
Filed:
Sep. 10, 1992
Applicant:
Inventors:
Gregory D Berger, Belle Mead, NJ (US);
Robert W Marquis, Jr, Iselin, NJ (US);
Albert J Robichaud, Stirling, NJ (US);
Edward M Scolnick, Wynnewood, PA (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; A61K / ; C07D / ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
514452 ; 514422 ; 514414 ; 514406 ; 514397 ; 514382 ; 514374 ; 514365 ; 514338 ; 514333 ; 514321 ; 514256 ; 514253 ; 5142338 ; 5142282 ; 546256 ; 546270 ; 546197 ; 546187 ; 548518 ; 548517 ; 548455 ; 548454 ; 5483644 ; 548253 ; 5483117 ; 548236 ; 548204 ; 549363 ; 549310 ; 549229 ; 549 60 ; 549 58 ; 549 28 ; 549 23 ; 549 13 ;
Abstract
Disclosed herein are compounds of structural formula (I) ##STR1## which are useful as cholesterol lowering agents. These compounds are also useful as inhibitors of squalene synthase, inhibitors of fungal growth, inhibitors of farnesyl-protein transferase and farnesylation of the oncogene protein Ras. These compounds are also useful in the treatment of cancer.