The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 1993
Filed:
Sep. 02, 1992
Surendra Gokhale, Basel, CH;
Markus Schlageter, Bottmingen, CH;
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
1,2,3,4-Tetrahydro-2-isoquinoline-derivatives of the formula ##STR1## wherein R signifies hydroxy, lower alkylamino, lower alkoxy or phenyl-C.sub.2-6 -alkoxy which can carry one or more lower alkyl or lower alkoxy substituents on the phenyl ring, can be manufactured by cyclizing a phenethylamine derivative of the formula ##STR2## wherein Z signifies benzyloxycarbonyl and R' signifies hydroxy, lower alkylamino, lower alkoxy or phenyl-lower-alkoxy which can carry one or more lower alkyl or lower alkoxy substituents on the phenyl ring, with formaldehyde in the presence of sulphuric acid in acetic acid to a corresponding tetrahydroisoquinoline derivative of the formula ##STR3## and cleaving off the group Z in the compound obtained.