The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 1993
Filed:
Dec. 13, 1992
David G Wettlaufer, Phillipsburg, NJ (US);
Gregory M Shutske, Flemington, NJ (US);
Peter A Nemoto, Piscataway, NJ (US);
Hoechst-Roussel Pharmaceuticals Incorporated, Somerville, NJ (US);
Abstract
This invention relates to 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols of the formula ##STR1## wherein X is ##STR2## or loweralkyl; Y is hydrogen, halogen, loweralkyl, loweralkoxy, trifluoromethyl, nitro or amino; R is H when the bond between the oxygen atom and the carbon atom in question is a single bond; otherwise the dotted line signifies part of a double bond to the oxygen atom; R.sub.1 is hydrogen, loweralkyl or arylloweralkyl; R.sub.2 and R.sub.3 are independently hydrogen, loweralkyl or arylloweralkyl, or R.sub.2 and R.sub.3 taken together with the nitrogen atom form an optionally substituted heterocycle selected from the group consisting of piperidinyl, pyrtolidinyl, morpholinyl, imidazol-1-yl, 1-piperazinyl, said substituents being hydrogen or loweralkyl; 4-substituted-1-piperazinyl of the formula where R.sub.6 is loweralkyl, aryl, arylloweralkyl, ##STR3## 2-pyrimidyl, ##STR4## 2-pyridinyl of the formula ##STR5## or 4-pyridinyl of the formula ##STR6## 4-substituted-1-piperidinyl of the formula ##STR7## wherein R.sub.7 is hydrogen, loweralkyl, aryl, arylloweralkyl, 2-pyridinyl of the formula ##STR8## 4-pyridinyl of the formula ##STR9## 2-pyrimidinyl of the formula arylcarbonyl, ##STR10## R.sub.8 is hydrogen or --OH; R.sub.4 is hydrogen, loweralkoxycarbonyl or aryloxycarbonyl; Z is chlorine, bromine or fluorine; m is an integer of 1 to 4; n is an integer of 1 to 4 or a pharmaceutically acceptable acid addition salt thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as antipsychotic agents and analgesic agents.