The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 1993
Filed:
Jul. 10, 1992
Patrick R Connelly, Groton, MA (US);
Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);
Abstract
A temperature gradient calorimeter and method of calculating heats of reactions is disclosed. The calorimeter has a two dimensional array of reaction chambers located in a thermally conductive substrate. A first heat transfer medium is in thermal contact with the thermal conductive substrate and is located at one region of the array of reaction chambers. A second heat transfer medium is in thermal contact with the thermal conductive substrate and is located on the opposite side of the array from the first heat transfer medium. The first and second heat transfer mediums are at two different temperatures. That temperature difference produces a temperature gradient across the array of reaction chambers. The fluorescence intensities are measured for reactant samples located in the array of reaction chambers. By inserting the fluorescence intensity data into thermodynamic equations expressing the degree of advancement and the heat of reaction, the heat of reaction for the reaction process of the sample can be determined.