The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 1993
Filed:
May. 04, 1992
Applicant:
Inventors:
Quirico Branca, Basel, CH;
Albrecht Edenhofer, Riehen, CH;
Eva-Maria Gutknecht, Buggingen-Seefelden, DE;
Werner Neidhart, Freiburg im Breisgau, DE;
Henri Ramuz, Birsfelden, CH;
Wolfgang Wostl, Grenzach-Wyhlen, DE;
Assignee:
Hoffmann-La Roche Inc., Nutley, NJ (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K / ; C07K / ; C07D / ; A61K / ;
U.S. Cl.
CPC ...
514 18 ; 514 19 ; 530330 ; 530331 ; 544 60 ; 544124 ; 544132 ; 544139 ; 544140 ; 544141 ; 544143 ; 544284 ; 544324 ; 544353 ; 544370 ; 548150 ; 548165 ; 548190 ; 548218 ; 5482664 ; 5483381 ; 5483385 ; 930 21 ; 930 24 ; 546 84 ; 546153 ; 546276 ; 546241 ; 546101 ; 546104 ; 546109 ; 546208 ;
Abstract
Compounds which are amino acid derivatives and have the formula ##STR1## in which R.sup.1 is hydrogen or methyl, R.sup.2 is ethyl, propyl or imidazol-4-yl, R.sup.3 is isobutyl, cyclohexylmethyl or benzyl, and A is defined as herein are useful as renin inhibitors.