The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 28, 1993

Filed:

Jan. 29, 1992
Applicant:
Inventors:

Olavi Siiman, Davie, FL (US);

Alexander Burshteyn, Miami Lakes, FL (US);

Assignee:

Coulter Corporation, Miami, FL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C08B / ; C07H / ; A61K / ; A61K / ;
U.S. Cl.
CPC ...
536112 ; 252 6253 ; 252 6254 ; 536121 ; 424-11 ; 424-71 ; 424-9 ; 424 858 ; 424 941 ; 424 943 ; 424 9467 ; 424460 ; 424461 ; 424491 ; 424493 ; 424617 ; 424618 ; 424646 ; 424649 ;
Abstract

The invention related generally to the preparation of colloidal metal(O) particles having a crosslinked aminodextran coating with pendent amine groups attached thereto. The aminodextran acts as both a reductant for reducing metal ions to metal(O) particles and as the protective agent which coats the metal(O) particles thus formed. After stabilizing the aminodextran coating by use of a crosslinking agent, the coated particles can be used to covalently bind proteins. The resulting protein containing colloidal particles can be used as markers in optical and electron microscopy, in immunological and biological assays, and possibly as therapeutic agents.


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