The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 21, 1993

Filed:

Mar. 04, 1991
Applicant:
Inventors:

Hiromi Okushima, Kawasaki, JP;

Akihiro Tobe, Yokohama, JP;

Makio Kobayashi, Machida, JP;

Tetsuro Shimpuku, Setagaya, JP;

Hideki Bessho, Zama, JP;

Junko Hayashi, Itabashi, JP;

Asami Seino, Yokohama, JP;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C / ; C07D / ; C07D / ; A61K / ;
U.S. Cl.
CPC ...
514399 ; 5483361 ; 5483385 ; 5483395 ; 5483415 ; 5483431 ; 5483435 ; 548180 ; 5483097 ; 544334 ; 544335 ; 544358 ; 546149 ; 546176 ; 546330 ; 558388 ; 558389 ; 558392 ;
Abstract

Disclosed are antihypertensive pharmaceutical compositions and compounds which include the thiocarbamoylacetonitrile having the formula: ##STR1## wherein: R.sup.1 is selected from the group consisting of hydrogen, a C.sub.1 to C.sub.6 alkyl, a C.sub.3 to C.sub.6 cycloalkyl or --(CH.sub.2).sub.n --A (where A is selected from the group consisting of a C.sub.6 to C.sub.12 aryl, a 5- or 6-membered heterocyclic group or a fused heterocyclic group constituted by 9 or 10 atoms, each of which may be substituted by at least one substitute group selected from a C.sub.1 to C.sub.6 alkyl and a halogen and n is 0 or an integer of 1 to 6),


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