The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 1993
Filed:
Apr. 17, 1992
Applicant:
Inventors:
Yiu-Kuen T Lam, Plainsboro, NJ (US);
Deborah L Zink, Manalapan, NJ (US);
David L Williams, Jr, Hatfield, PA (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07K / ;
U.S. Cl.
CPC ...
514 11 ; 514-9 ; 514 10 ; 530317 ; 435 711 ;
Abstract
Novel cyclic depsipeptides derived from a culture of Microbispora are antagonists of the receptor for endothelin, a potent vasoconstrictor, and are thus useful in treating cardiovascular disorders. Endothelin has other physiological effects, and the endothelin receptor antagonists of the present invention thus also have other therapeutic uses. The compounds are cyclical depsipeptides of N-(pyrrol-2-carboxy) - L-phe, D-allo-Thr, D-Phe, D-Ala, D- or L-dihydroxyphenyl-Gly, and D-dihydroxyphenyl-Gly.