The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 1993
Filed:
Sep. 25, 1987
Applicant:
Inventors:
Robert S Lees, Brookline, MA (US);
Robert S Langer, Jr, Somerville, MA (US);
Claudy J Mullon, Burlington, MA (US);
Hugh D Conlon, Medford, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C12N / ; C12N / ; A61M / ;
U.S. Cl.
CPC ...
424 946 ; 604-5 ; 604-6 ; 435-2 ; 435174 ; 435177 ; 435178 ; 435197 ; 435198 ;
Abstract
A method and apparatus for reducing the levels of low density lipoproteins (LDL) in blood is disclosed. The LDL is contacted with an enzyme which modifies it in a manner such that the LDL is rapidly removed endogenously by the patients' own metabolic processes. The enzyme may be introduced into the patient by injection, transdermal transport, nasal insufflation and ingestion. Additionally, the enzyme may be contained in a reactor for both in vivo and extracorporeal use.