The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 20, 1993
Filed:
Mar. 25, 1988
Stephen J Peroutka, Stanford, CA (US);
Josef Pitha, Baltimore, MD (US);
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Abstract
Compounds that selectively bind 5-HT.sub.1A receptors in preference to other 5-HT receptors are provided along with methods for their use. Such compounds have the formula ##STR1## wherein A is an aromatic group selected to provide, with the glycidyl residue that forms the next portion of the molecule, a 5-HT-like portion of the molecule that represents the primary binding site of the molecule with a 5-HT receptor: X represents a quarternary carbon and its attached alkyl groups: Y represents a hydrocarbon linking group: Z represents hydrogen or an organic group containing up to 12 carbon and/or heteroatoms in its skeletal structure: and R.sup.1 and R.sup.2 independently represent hydrogen or an alkyl group. The aromatic group is most preferably indole or an indole derivative.