The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 20, 1993
Filed:
Dec. 06, 1991
Applicant:
Inventors:
Lars J Knutsen, Vedbaek, DK;
Knud E Andersen, Bagsvaerd, DK;
Anker S Jorgensen, Copenhagen, DK;
Ursula Sonnewald, Ballerup, DK;
Assignee:
Novo Nordisk A/S, Bagvaerd Denmark, DK;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; C07D / ; A61K / ;
U.S. Cl.
CPC ...
514357 ; 514399 ; 514400 ; 514427 ; 514524 ; 514640 ; 546333 ; 548561 ; 5483325 ; 5483265 ; 558418 ; 564256 ;
Abstract
Novel O-alkylated oximes of the general formula I ##STR1## wherein R.sup.1 and R.sup.2 are optionally substituted aromatic or heteroaromatic rings, R.sup.3 is hydrogen or lower alkyl, R.sup.4 is a nitrogen containing, substituted ring or an amino group carrying a substituted ring, and n and m independently are 0, 1 or 2, are potent inhibitors of GABA re-uptake from the synaptic cleft.