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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5227492 B1

PDFFull Text
Date of Patent:
Jul. 13, 1993

Filed:

Jun. 30, 1992

Diurea derivatives useful as medicaments and processes for the

Applicant:
Inventors:

Noriki Ito, Saitama, JP;

Tomoyuki Yasunaga, Tokyo, JP;

Yuichi Iizumi, Chiba, JP;

Tomio Araki, Tokyo, JP;

Assignee:

Yamanouchi Pharmaceutical Co., Ltd., Tokyo, JP;

Attorney:

Burgess, Ryan & Wayne

Primary Examiner:

Richard L Raymond

Assistant Examiner:

Shailendra Kumar

Int. Cl.
CPC ...
C07D / ;
U.S. Cl.
CPC ...
546265 ; 546308 ; 546309 ; 564 27 ; 564 29 ; 564 50 ; 564 52 ; 564 53 ; 564 54 ; 564 55 ; 564 56 ; 564 57 ; 564 59 ;
Abstract

Diurea derivatives are provided which can be represented by the following general formula and salts thereof: ##STR1## Illustrative derivatives include 1,3-bis[[1-cycloheptyl-3-(3-pyridyl)ureido]-methyl]benzene, 1,3-bis[[1-cycloheptyl-3-(2-pyridyl)ureido]-methyl]benzene, and 1,3-bis[[1-cycloheptyl-3-(4-pyridyl)ureido]-methyl]benzene. The above compounds inhibit acyl-coenzyme A cholesterol acyltransferase (ACAT enzyme), and thereby control the accumulation of cholesterol ester to the smooth muscle of arterial wall in the blood vessel.

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Ito, Noriki. (1993). Diurea derivatives useful as medicaments and processes for the (U.S. Patent No. 5227492). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5227492

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