The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 1993
Filed:
Oct. 11, 1991
Applicant:
Inventors:
Yuji Sato, Tokyo, JP;
Hiroko Sato, Tokyo, JP;
Iwao Yoshida, Kanonji, JP;
Atsushi Imaizumi, Hino, JP;
Assignees:
Teijin Limited, Osaka, JP;
National Institute of Health, Tokyo, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C12P / ;
U.S. Cl.
CPC ...
424 92 ; 424 88 ; 530350 ; 435 701 ; 435 711 ; 435 712 ; 435243 ; 435244 ; 435822 ; 4352521 ;
Abstract
A Bordetella pertussis variant which produces a pertussis toxin mutant protein partially devoid of subunits. When the variants of the present invention are cultured, a pertussis toxin mutant protein partially devoid of subunits, particularly at least subunit S1, can be harvested from the culture. The thus-obtained pertussis toxin mutant protein partially devoid of subunits can be applied to the preparation of a pertussis vaccine by a conventional method.