The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 1993
Filed:
Nov. 14, 1990
Applicant:
Inventors:
Girish Ranadive, Pittsburgh, PA (US);
Howard S Rosenzweig, Pittsburgh, PA (US);
Michael Epperly, Pittsburgh, PA (US);
William Bloomer, Pittsburgh, PA (US);
Assignee:
University of Pittsburgh, Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07K / ; C07K / ;
U.S. Cl.
CPC ...
424-11 ; 5303881 ; 5303911 ; 5303913 ; 5303915 ; 5303917 ; 5303919 ; 424-9 ; 424 8591 ; 435-71 ; 436512 ;
Abstract
A method of selectively modifying an immunoglobulin having at least one Fab region and at least one Fc region, each region having an isoelectric point wherein said isoelectric point of the Fab fragment of said immunoglobulin is different than the isoelectric point of the Fc fragment of the immunoglobulin, said method comprising modification of the immunoglobulin at a pH between the respective isoelectric points of the Fab and Fc fragments of the immunoglobulin.