The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 13, 1993
Filed:
Mar. 09, 1992
Shieh-Shung T Chen, Morganville, NJ (US);
Byron H Arison, Watchung, NJ (US);
George M Garrity, Westfield, NJ (US);
Edward S Inamine, Rahway, NJ (US);
Sagrario Mochales, Madrid, ES;
Linda S Wicker, Westfield, NJ (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
Described is a new microorganism, Actinoplanacete sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The microorganism acts as a demethylating agent and can produce the new immunosuppressants, 'demethomycin' (L-682,993) a C-31 demethylated analog of L-679,934, and 'demethimmunomycin' (L-683,742) a C-31 demethylated analog of L-683,590, under novel fermentation conditions. These macrolide immunosuppressants are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.