The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 1993
Filed:
Dec. 18, 1990
Applicant:
Inventors:
Thomas E Starzl, Pittsburgh, PA (US);
Satoru Todo, Pittsburgh, PA (US);
Antonio Francavilla, Pittsburgh, PA (US);
Assignee:
Fujisawa Pharmaceutical Company, Ltd., Osaka, JP;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ;
U.S. Cl.
CPC ...
514294 ; 514411 ; 514838 ; 514894 ;
Abstract
Macrolide compounds having the structure shown below ##STR1## wherein R.sup.1 is hydroxy or protected hydroxy, R.sup.2 is hydrogen, hydroxy or protected hydroxy, R.sup.3 is methyl, ethyl, propyl or allyl, R.sup.4 is hydroxy, methoxy or oxo, n is 1 or 2 and the symbol of a line and a dotted is a single bond or a double bond, provided that R.sup.2 is not protected hydroxy where R.sup.4 is hydroxy or oxo are used to treat hepatic disease and regenerate liver tissue by facilitating hypertrophy and hyperplasia of hepatocytes.