The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 1993
Filed:
Jul. 06, 1990
Applicant:
Inventors:
John M Maraganore, Concord, MA (US);
John W Fenton, II, Malden Bridge, NY (US);
Toni Kline, New York, NY (US);
Assignees:
Biogen, Inc., Cambridge, MA (US);
Health Research, Inc., Albany, NY (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07K / ; C07K / ;
U.S. Cl.
CPC ...
514 13 ; 514 12 ; 514 14 ; 530326 ; 530327 ; 530325 ; 530324 ; 623 11 ;
Abstract
This invention relates to novel biologically active molecules which bind to and inhibit thrombin. Specifically, these molecules are characterized by a thrombin anion-binding exosite association moiety (ABEAM); a linker portion of at least 18 .ANG. in length; and a thrombin catalytic site-directed moiety (CSDM). This invention also relates to compositions, combinations and methods which employ these molecules for therapeutic, prophylactic and diagnostic purposes.