The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 1993
Filed:
Nov. 02, 1990
Applicant:
Inventors:
Martin Heinrich, Darmstadt, DE;
Wolfgang Ebeling, Bickenbach, DE;
Wolfgang Brummer, Alsbach-Hahnlein, DE;
Assignee:
Merck Patent Gesellschaft mit beschrankter Haftung, Darmstadt, DE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
435 691 ; 435190 ; 4352523 ; 43525233 ; 435248 ; 935 39 ; 935 43 ; 935 61 ; 935 72 ; 935 73 ;
Abstract
The invention relates to a process for achieving high, thermally-induced expression rates, which last for a relatively long period of time, of proteins in recombinant cells, preferably in E. coli cells, by optimizing cell density, induction temperature and supplemented amino-acid-containing substrates.