The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 23, 1993

Filed:

Sep. 30, 1991
Applicant:
Inventors:

Yoshikazu Hasegawa, Ibaragi, JP;

Akira Hashimoto, Ryugasaki, JP;

Assignee:

Eisai Co., Ltd., Tokyo, JP;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12M / ; C12M / ;
U.S. Cl.
CPC ...
435285 ; 435284 ; 435289 ; 435311 ; 435315 ; 21032167 ; 21032169 ;
Abstract

Culture medium is circulated from a culture medium tank, through a first main duct, through a cell cultivating vessel containing therein a bundle of hollow threads, through a second main duct and back to the culture mediun tank. The first main duct is provided at an intermediate point with a vibrating columnar pump adapted to pulsate the culture medium and to vibrate outer surfaces of said hollow threads. The second main duct is provided along a tail end portion with a container serving to capture solids in the culture medium. The first main duct branches into a first sub-duct which is provided with sensors used to detect and regulate a quantity of gas mixture in the culture medium. Similarly, the second main duct branches into a second sub-duct which is provided with sensors used to detect a quantity of gas mixture in the culture medium which has been used for cell cultivation so that a level of cell metabolism occurring in the hollow threads may be detected and a flow velocity of the culture medium may be correspondingly regulated.


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