The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 1993
Filed:
Mar. 13, 1992
Applicant:
Inventors:
Dee W Brooks, Libertyville, IL (US);
Karen E Rodriques, Stowe, MA (US);
Assignee:
Abbott Laboratories, Abbott Park, IL (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
514445 ; 514 63 ; 514351 ; 514357 ; 514512 ; 514575 ; 514469 ; 514470 ; 514471 ; 514438 ; 514443 ; 514336 ; 546283 ; 546284 ; 546291 ; 546332 ; 546300 ; 549 51 ; 549 54 ; 549 55 ; 549 58 ; 549 65 ; 549 76 ; 549 77 ; 549467 ; 549493 ; 549469 ; 549479 ; 560313 ; 562621 ; 562622 ; 562623 ; 562874 ; 556436 ; 558262 ; 552 35 ;
Abstract
Compounds of the structure ##STR1## where M is a pharmaceutically acceptable cation or a metabolically cleavable group, R is alkyl, cycloalkyl or --NR.sup.1 R.sup.2, where R.sup.1 and R.sup.2 are hydrogen, alkyl, cycloalkyl or alkanoyl, and A is optionally substituted alkyl, cycloalkyl, carbocyclic aryl, benzo[b]furyl, thienyl, or benzo[b]thienyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.