The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 09, 1993
Filed:
Jan. 13, 1989
Michael B Brenner, Sherborn, MA (US);
Jonathan Seidman, Milton, MA (US);
Jack L Strominger, Lexington, MA (US);
Stephen H Ip, Sudbury, MA (US);
Michael S Krangel, Chapel Hill, NC (US);
Hamid Band, Boston, MA (US);
T Cell Sciences, Inc., Cambridge, MA (US);
Dana Farber Cancer Institute, Boston, MA (US);
President & Fellows of Harvard College, Boston, MA (US);
Abstract
The present invention is directed to purified polypeptides comprising the .gamma. T cell antigen receptor (TCR) polypeptide, the .delta. TCR polypeptide, a .gamma., .delta. TCR complex, or a fragment thereof containing an epitope. The invention also relates to nucleic acid sequences encoding such polypeptides, and subsequences thereof. In specific embodiments, the invention relates to nucleic acid sequences comprising variable, diversity, joining, or constant regions of the .delta. TCR gene sequence. The invention also relates to monoclonal antibodies specifically reactive with an epitope of the gamma or delta TCR polypeptides. In specific embodiments, these antibodies are reactive with the delta constant region, the delta variable region, or gamma constant region. Such antibodies can be identified by detecting co-modulation of the CD3 antigen. In another embodiment, the invention relates to compositions comprising substantially purified cells which express both a .gamma., .delta. TCR and the CD4 antigen. The invention also relates to a composition comprising cells which express a .gamma., .delta. TCR that is not associated with a CD3 complex.