The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 19, 1993
Filed:
Nov. 29, 1990
Applicant:
Inventors:
John G Bauman, Alameda, CA (US);
Randolph C Wirsching, Livermore, CA (US);
Assignee:
Berlex Biosciences Inc., Alameda, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; C07H / ;
U.S. Cl.
CPC ...
544251 ; 544277 ; 536 274 ; 536 2671 ;
Abstract
This invention pertains to novel methods of synthesizing fludarabine, fludarabine phosphate and related nucleoside pharmacologic agents utilizing 6-azido-2-fluoropurine as a novel intermediate. In particular this invention pertains to a synthesis of fludarabine where the relatively low yield fluorination step is done before the costly coupling step.