The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 22, 1992
Filed:
Jul. 03, 1991
Applicant:
Inventors:
Jonathan D Bloom, Hartsdale, NY (US);
Minu D Dutia, West Nyack, NY (US);
Assignee:
American Cyanamid Company, Stamford, CT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07C / ;
U.S. Cl.
CPC ...
514616 ; 564159 ; 554 57 ;
Abstract
New thioester and ester, amide and ketone isostere analogs of oleoyl coenzyme A, useful as antiatherosclerotic agents, are provided. The compounds have the formula: ##STR1## wherein A is selected from the group consisting of ##STR2## Y is selected from the group consisting of --S--, --O--, --NH-- and (--CH.sub.2 --).sub.n wherein n=1 to 4; and Z is selected from the group consisting of alkyl (C.sub.1 -C.sub.6), ##STR3## wherein R=Hydrogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 acyl, and ##STR4##