The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 22, 1992
Filed:
Jun. 14, 1988
David S Schrump, Chicago, IL (US);
Koichi Furukawa, New York, NY (US);
Hiroshi Yamaguchi, Nagoya, JP;
Kenneth O Lloyd, Bronx, NY (US);
Lloyd J Old, New York, NY (US);
Sloan-Kettering Institute for Cancer Research, New York, NY (US);
Abstract
This invention provides a composition useful for diagnosing cancer which specifically recognizes a galactosyl-globoside. Preferably, the composition is a monoclonal antibody which specifically recognize the galactosyl-globoside antigen, gal-Gb4. Additionally, the present invention provides two hybridoma cell lines, designated J309 and D579, which produce monoclonal antibodies that specifically recognize gal-Gb4. The invention also provides a method of diagnosing a carcinoma which comprises contacting a sample from a human subject with a composition which specifically recognizes a galactosyl-globoside antigen and is labeled with a detectable moiety, under suitable conditions so as to form a detectable complex. The amount of formed complex is then quantified and correlated with values obtained from subjects devoid of carcinomas. Another aspect of the invention provides a method of treating carcinoma which comprises administering an effective amount of galactosyl-globoside or an analog thereof and a pharmaceutically carrier to stimulate the body production of antibodies.