The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 1992
Filed:
Feb. 10, 1992
Applicant:
Inventors:
Paul G Abrams, Seattle, WA (US);
John M Reno, Brier, WA (US);
Alan R Fritzberg, Edmonds, WA (US);
Ananthachari Srinivasan, Kirkland, WA (US);
David C Anderson, Seattle, WA (US);
Assignee:
NeoRx Corporation, Seattle, WA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; A61K / ;
U.S. Cl.
CPC ...
424-11 ; 424-9 ; 424-4 ; 424-71 ; 424 8591 ; 424 9463 ; 424 9464 ; 424717 ; 424720 ; 514474 ; 514562 ; 514836 ; 514922 ; 5303911 ; 5303915 ; 5303919 ; 530402 ; 530807 ;
Abstract
A process for reducing the non-target organ accumulation of immunoconjugates administered in vivo during therapeutic or diagnostic procedures involves the use of immunoconjugates comprising linkers that are cleavable at the non-target organs. The linkers are cleavable under conditions present, or induced, at one or more non-target organs, which include the kidneys or the liver.