The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 1992
Filed:
Aug. 07, 1989
Applicant:
Inventors:
David C Anderson, Seattle, WA (US);
A Charles Morgan, Jr, Edmonds, WA (US);
Paul G Abrams, Seattle, WA (US);
Alan R Fritzberg, Edmonds, WA (US);
Everett J Nichols, Seattle, WA (US);
Assignee:
NeoRx Corporation, Seattle, WA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K / ; C07K / ; C07K / ; C07K / ; C07K / ; C07K / ; C07K / ; A61K / ;
U.S. Cl.
CPC ...
5303913 ; 530324 ; 530325 ; 530326 ; 530327 ; 530328 ; 530329 ; 530330 ; 530377 ; 5303911 ; 5303915 ; 5303917 ; 5303919 ; 530306 ; 530307 ; 530308 ; 530313 ; 530323 ; 530351 ; 530395 ; 530399 ; 530403 ; 530408 ; 530409 ; 530410 ; 424-11 ; 424-9 ; 424 8591 ; 435188 ; 514-2 ; 514-8 ; 514 12 ; 514 21 ; 514 13 ; 514 14 ; 514 15 ; 514 16 ; 514 17 ; 514 18 ;
Abstract
Covalently-linked complexes (CLCs) for targeting a defined population of cells, comprising a targeting protein; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety is capable of promoting CLC-target cell interaction are disclosed. Methods for using the claimed CLCs to obtain enhanced in vivo cytotoxicity and enhanced in vivo imaging are also described.