The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 1992
Filed:
Jul. 27, 1990
Applicant:
Inventors:
Joseph I DeGraw, Sunnyvale, CA (US);
William T Colwell, Menlo Park, CA (US);
Francis M Sirotnak, New York, NY (US);
Assignees:
SRI International, Menlo Park, CA (US);
Sloan-Kettering Institute for Cancer Research, New York, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; C07D / ;
U.S. Cl.
CPC ...
424436 ; 424408 ; 424456 ; 424464 ; 424D / ; 514258 ; 514937 ; 514944 ; 514960 ; 514962 ; 514966 ; 544260 ; 544279 ;
Abstract
8,10-Dideazatetrahydrofolic acid derivatives of the formula: ##STR1## where R.sub.1 and R.sub.2 are selected from hydrogen and alkyl having from one to about eight carbon atoms and the carboxylates and acid addition salts thereof, showing strong inhibition of L1210 murine leukemia cells in culture, modest inhibition of glycinamide ribotide transformylase and aminoimidazole carboxamide ribotide transferase, and insignificant inhibition of dihydrofolate reductase and thymidylate synthase enzymes.