The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 1992
Filed:
Apr. 21, 1989
Applicant:
Inventors:
Gray Shaw, Bedford, MA (US);
Geertruida Veldman, Sudbury, MA (US);
Joseph L Wooters, Brighton, MA (US);
Assignee:
Genetics Institute, Cambridge, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K / ; C12N / ;
U.S. Cl.
CPC ...
530351 ; 530402 ; 530404 ; 530405 ; 530403 ; 930141 ; 435 695 ; 435 6952 ; 424 851 ; 424 852 ; 424 8591 ; 525 541 ;
Abstract
Cysteine added variants ('CAVs') of interleukin-3 are provided having one or more cysteine residues substituted for selected naturally occurring amino acid residues, or inserted into the polypeptide sequence, and preferably being further modified by deletion of certain N-terminal amino acids. Such CAVs may be additionally modified by the coupling of sulfhydryl reactive compounds to the introduced cysteine residue(s) without loss of bioactivity to produce selected homogeneously modified IL-3 and improved pharmaceutical compositions containing the same.