The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 1992
Filed:
Apr. 06, 1990
Fujisawa Pharmaceutical Company, Ltd., Osaka, JP;
Abstract
Peptide compounds having Substance P antagonism of the formula: ##STR1## wherein R.sup.1 is lower alkyl, aryl, arylamino, pyridyl, pyrrolyl, pyrazolopyridyl, quinolyl, or a group of the formula: ##STR2## wherein the symbol of a line and dotted line is a single bond or a double bond; X is CH or N; Z is O, S or NH; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is hydrogen or hydroxy; R.sup.4 is lower alkyl which may have suitable substituent(s); R.sup.5 is ar(lower)alkyl which may have suitable substituent(s) or pyridyl(lower)alkyl, or R.sup.4 and R.sup.5 are linked together to form benzene-condensed lower alkylene; A is an amino acid residue excepting D-Trp, which may have suitable substituent(s); and Y is bond, lower alkylene or lower alkenylene; and their pharmaceutically acceptable salts are disclosed.