The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 29, 1992

Filed:

Aug. 23, 1990
Applicant:
Inventors:

David C Cook, London, GB;

Terance W Hart, Brentwood, GB;

Iain M Mc Lay, Loughton, GB;

Malcolm N Palfreyman, Upminster, GB;

Brian W Sharp, Hornchurch, GB;

Roger J Walsh, Rayleigh, GB;

Assignee:

Rhone-Poulenc Sante, Antony, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
514314 ; 514212 ; 514277 ; 514311 ; 514318 ; 514332 ; 514346 ; 514357 ; 514880 ; 514375 ; 540597 ; 546164 ; 546175 ; 546194 ; 546265 ; 546266 ; 546267 ; 546281 ; 546261 ; 546263 ; 546264 ; 546291 ; 546293 ; 546300 ; 546301 ; 546302 ; 546331 ; 546340 ;
Abstract

Therapeutically useful thioformamide derivatives of the formula: ##STR1## wherein R represents alkyl, Het represents pyrid-3-yl, isoquinolin-4-yl, tetrahydroquinolin-3-yl, quinolin-3-yl, pyridazin-4-yl, pyrimid-5-yl, thiazol-5-yl, thieno[2,3-b]-pyridin-5-yl, pyrazin-2-yl, indol-3-yl and thieno[3,2-b]-pyridin-6-yl, Y represents ethylene, methylene or a valency bond, and X represents carbonyl, hydroxymethylene, >C.dbd.NOR.sup.1, >C.dbd.NN(R.sup.1).sub.2 or >C.dbd.NN(R.sup.1)CON(R.sup.1).sub.2 in which R.sup.1 represents hydrogen or optionally substituted alkyl, benzyl, phenethyl, 1-naphthylmethyl, 2-naphthylmethyl or pyrid-3-ylmethyl, or two R.sup.1 substituents on the same nitrogen atom may together form an optionally substituted alkylene radical chain and salts thereof, processes for their preparation and compositions containing them are described.


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