The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 1992
Filed:
Dec. 22, 1988
Applicant:
Inventors:
A Charles Morgan, Jr, Edmonds, WA (US);
Gowsala Pavanasasivam, Edmonds, WA (US);
Assignee:
NeoRx Corporation, Seattle, WA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ;
U.S. Cl.
CPC ...
424 858 ; 424 8591 ; 5303871 ; 5303881 ; 5303888 ; 5303901 ; 5303917 ; 530392 ; 530393 ; 530403 ; 530405 ; 530422 ; 530828 ; 530861 ; 514-2 ; 514-8 ; 514 21 ; 514937 ; 514975 ; 252351 ;
Abstract
Methods are disclosed for increasing the solubility of antibodies and their radioisotope, toxin, or drug immunoconjugates and for reducing the non-specific uptake of antibody, either conjugated or unconjugated, into the RES organs such as via Fc receptor-mediated mechanisms. The methods involve incubation of the reactive component with amphipathic molecules, such as an anionic detergent, to achieve the desired result. A preferred anionic detergent in this regard is sodium dodecylsulfate.