The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 1992
Filed:
Feb. 15, 1990
Applicant:
Inventors:
Thoru Pederson, Worcester, MA (US);
Sudhir Agrawal, Shrewsbury, MA (US);
Sandra Mayrand, Shrewsbury, MA (US);
Paul C Zamecnik, Shrewsbury, MA (US);
Assignee:
The Worcester Foundation for Experimental Biology, Shrewsbury, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
536 27 ; 435183 ; 935-8 ; 935 22 ; 536 28 ; 536 29 ;
Abstract
A method of site-directed alteration (removal or removal followed by replacement) of selected nucleotides in an RNA molecule, as well as to mixed phosphate backbone oligonucleotides useful in the method. It further relates to a method of producing polypeptides or proteins encoded by the RNA molecule altered by the present method. Through use of the present method, site-directed cleavage of an RNA molecule is effected, followed by excision of the selected or target segment of the RNA molecule.
Published as:
CA2076037A1; WO9112323A1; US5149797A; EP0515511A1; JPH05506355A; US5366878A; EP0515511B1; ATE141326T1; DE69121391D1; ES2090314T3; DK0515511T3; GR3021278T3; DE69121391T2; US5635377A;