The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 1992
Filed:
Nov. 01, 1990
Applicant:
Inventors:
Milton B Yatvin, Portland, OR (US);
David W Parks, Seattle, WA (US);
Ronald W McClard, Portland, OR (US);
Michael H Stowell, Salt Lake City, UT (US);
John F Witte, Portland, OR (US);
Assignee:
State of Oregon, Portland, OR (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H / ; A61K / ; A61K / ;
U.S. Cl.
CPC ...
536 29 ; 424450 ; 514 51 ; 514 78 ; 530300 ; 530331 ; 530329 ; 544243 ; 564153 ;
Abstract
This invention relates to a novel method of drug targeting which comprises covalently binding a drug to a lipid carrier. This composition has the unique ability to both enhance the rate at which an antineoplastic or antiviral drug crosses the plasma membrane, and to direct the drug within the cell to specific organelles. The versatility of these conjugates may be further enhanced by including a spacer group between the drug and the lipid which may act to modulate drug release at the target site.