The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 1992
Filed:
Jul. 10, 1990
Alexander H Chu, Buffalo Grove, IL (US);
Abbott Laboratories, Abbott Park, IL (US);
Abstract
A process for the manufacture of vancomycin which does not require preparation of a phosphate intermediate. The process consists of loading a vancomycin onto a suitable adsorbent and eluting the vancomycin solution therefrom with an ammonium solvent followed by loading the solution onto a second adsorbent and eluting the purified, vancomycin therefrom with a solvent of alcohol and acid. The purified vancomycin is then crystallized by adding a base solution in an amount sufficient to raise the pH of the vancomycin/base solution to a pH of about 9.5 to 10.5 followed by the addition of an organic solvent such as methanol. The crystallized vancomycin is then reslurried in an aqueous solution and then recrystallized by adding a base solution in an amount sufficient to raise the pH to about 9.5 to about 10.5, followed by the addition of an organic solvent such as methanol. The recrystallized vancomycin is dissolved and titrated with hydrochloric acid to a pH of about 3.0 to 3.5. Vancomycin HCl is precipitated from the solution using an organic solvent.