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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5149533 B1

PDFFull Text
Date of Patent:
Sep. 22, 1992

Filed:

Aug. 12, 1991

Modified t-pa with kringle-/replaced by another kringle

Applicant:
Inventors:

Eileen R Mulvihill, Seattle, WA (US);

Shinji Yoshitake, Yatabe, JP;

Yasunori Ikeda, Ushiku, JP;

Suguru Suzuki, Ushiku, JP;

Akira Hashimoto, Ryugasaki, JP;

Teruaki Yuzuriha, Sakura, JP;

Bjorn A Nexo, Soborg, DK;

Assignee:

ZymoGenetics, Inc., Seattle, WA (US);

Attorney:

Seed and Berry

Primary Examiner:

David L Lacey

Assistant Examiner:

Marianne Porta Allen

Int. Cl.
CPC ...
A61K / ; C12N / ; C12N / ; C07H / ;
U.S. Cl.
CPC ...
424 9464 ; 424 9463 ; 435226 ; 4352402 ; 4352523 ; 4353201 ; 435217 ; 435214 ; 536 27 ; 530324 ;
Abstract

Tissue plasminogen activator analogs exhibiting greater specificity for fibrin than native t-PA are disclosed. The analogs include the K1 domain of native t-PA replaced with another kringle domain mediating the binding of the analog to fibrin. The kringle contains six cysteine residues. The t-PA analogs may further include a variety of substitutions and modifications. Pharmaceutical compositions containing one or more of the t-PA analogs along with a physiologically acceptable carrier or diluent are also disclosed.

Find Patent Forward Citations

Mulvihill, Eileen. (1992). Modified t-pa with kringle-/replaced by another kringle (U.S. Patent No. 5149533). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5149533

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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