The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 1992
Filed:
Nov. 05, 1990
William T Phillips, San Antonio, TX (US);
Robert W Klipper, San Antonio, TX (US);
James H Timmons, Tacoma, WA (US);
Alan S Rudolph, Bowie, MD (US);
Board of Regents, The University of Texas System, Austin, TX (US);
The United States of America as represented by the Secretary of the Navy, Washington, DC (US);
Abstract
The invention relates to the efficient preparation of radionuclide labeled liposomes and radionuclide-labeled liposome-encapsulated protein. In particular, a .sup.99m Tc carrier is used to label preformed liposomes or liposome-encapsulated hemoglobin. .sup.99m Tc-labeled liposomes and liposome-encapsulated .sup.99m Tc labeled hemoglobin are highly stable in vitro and in vivo and are suitable for a variety of clinical uses, including biodistribution imaging studies. The invention also relates to a method of labeling neutrophils using .sup.99m technetium-labeled liposomes or liposome-encapsulated hemoglobin. A kit method useful for the convenient preparation of .sup.99m Tc-labeled liposomes or liposome-encapsulated hemoglobin for clinical use is also disclosed.