The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 1992
Filed:
Nov. 05, 1991
John F DeBernardis, Lindenhurst, IL (US);
Robert E Zelle, Grayslake, IL (US);
Fatima Z Basha, Lake Forest, IL (US);
Abbott Laboratories, Abbott Park, IL (US);
Abstract
The present invention includes compounds represented by the formula: ##STR1## wherein n is 0 or 1; R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are independently selected from hydrogen, hydroxyl, amino, alkylamino, alkylsulfonylamino, loweralkyl, loweralkoxy, halo, and thioalkoxy; R.sub.1 and R.sub.2 or R.sub.2 and R.sub.3 taken together can form a methylenedioxy or ethylenedioxy bridge; R.sub.10 is independently selected from hydrogen, loweralkyl, phenyl, and substituted phenyl; R.sub.5 is loweralkyl; R.sub.9 is hydrogen or loweralkyl; R.sub.6 and R.sub.8 are hydrogen; and R.sub.7 is ##STR2## wherein m is 0, 1 or 2; X is CH.sub.2, O, S or N--CH.sub.3 ; or R.sub.7 is ##STR3## wherein s is 0, 1, or 2; Z is C or N; R.sub.11 and R.sub.12 are independently selected from hydrogen, halo, hydroxy, methoxy, thiomethoxy, amino and loweralkyl, or R.sub.11 and R.sub.12 taken together can form a methylenedioxy or ethylenedioxy bridge; or R.sub.7 is ##STR4## wherein t is 0 or 1; or R.sub.5 and R.sub.9 taken together form a pyrrolidine ring and R.sub.6 and R.sub.8 are hydrogen and R.sub.7 is as described above; or R.sub.5 and R.sub.9 taken together form a pyrrolidine ring and then R.sub.6 is hydrogen and R.sub.7 and R.sub.8 taken together may form a phenyl, substituted phenyl, thienyl or furyl ring; or R.sub.5 and R.sub.8 taken together form a pyrrolidine ring and then R.sub.9 and R.sub.6 are hydrogen and R.sub.7 is phenyl, substituted phenyl, thienyl, or furyl; or R.sub.7 and R.sub.9 are hydrogen and R.sub.6 is benzyl, substituted benzyl, thienylmethyl, or furylmethyl; or a pharmaceutically acceptable salt thereof.