The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 1992
Filed:
Jun. 12, 1991
Donald W Graham, Mountainside, NJ (US);
John C Chabala, Westfield, NJ (US);
Tesfaye Biftu, Parlin, NJ (US);
Michael N Chang, Newtown, PA (US);
Yuan-Ching P Chiang, Piscataway, NJ (US);
Shu S Yang, Bridgewater, NJ (US);
Kathryn L Thompson, Westfield, NJ (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
Novel 1,3-Diaryl cyclopentanes of the following general formula were prepared. ##STR1## These compounds were found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and as such useful in the treatment or amelioration of various diseases or disorders mediated by the PAF, for example, hypotension, inflammation, nephritis, stroke and other cardiovascular disorders, asthma, allergic and skin diseases, peptic or stomach ulcer, shock, lung edema, psoriasis, adult respiratory distress syndrome, pain including dental pain, and aggregation of platelets.