The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 1992
Filed:
Apr. 07, 1988
Applicant:
Inventors:
Andreas Bachmair, Cologne, DE;
Daniel Finley, Cambridge, MA (US);
Alexander Varshavsky, Boston, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P / ; C12N / ; C12N / ; C12N / ; C12N / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
435 697 ; 435 691 ; 435 201 ; 435 711 ; 435 91 ; 435171 ; 4351721 ; 4351723 ; 4352402 ; 435254 ; 4353201 ; 435911 ; 435940 ; 536 27 ; 935-6 ; 935-9 ; 935 10 ; 935 22 ; 935 23 ; 935 24 ; 935 33 ; 935 34 ; 935 37 ; 935 42 ; 935 48 ; 935 49 ; 935 51 ; 935 59 ; 935 60 ; 935 61 ; 935 66 ; 935 68 ; 935 69 ; 935 70 ; 935 71 ;
Abstract
A method of designing or modifying protein structure at the protein or genetic level to produce specified amino-termini in vivo is described. The method is used to alter the metabolic stability and other properties of the protein or, alternatively, to artificially generate authentic amino-termini in proteins produced through artificial means. The method is based upon the introduction of the use of artificial ubiquitin-protein fusions, and the discovery that the in vivo half-life of a protein is a function of the amino-terminal amino acid of the protein.