The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 30, 1992
Filed:
Jun. 20, 1989
Ralph B Arlinghaus, Bellaire, TX (US);
James T Sparrow, Houston, TX (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Baylor College of Medicine, Houston, TX (US);
Abstract
Disclosed are peptidyl-resin conjugates made up of an immunogenic/antigenic peptide conjugated to a polyamide resin, wherein the peptide incorporates a helper T-cell epitope. The inclusion of a T-cell epitope in this peptide sequence provides particular benefits in the preparation of site-directed reagents intended as immunogens. In exemplary studies, a synthetic peptide predicted from Abelson murine leukemia virus abl oncogene (residues 389-403) was synthesized with a T-cell active epitope of 7 amino acids placed at its N-terminus (T-abl-resin). The T-abl-resin construct was found to greatly stimulate the immune response giving significantly higher specific antibody titers than abl-resin controls.