The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 02, 1992

Filed:

Mar. 09, 1987
Applicant:
Inventors:

Hisayuki Matsuo, Miyazaki, JP;

Kenji Kangawa, Miyazaki, JP;

Yujiro Hayashi, Neyagawa, JP;

Shinzo Oikawa, Kyoto, JP;

Takehiro Oshima, Takatsuki, JP;

Shoji Tanaka, Suita, JP;

Hiroshi Nakazato, Ibaraki, JP;

Yasunori Tawaragi, Ibaraki, JP;

Assignee:

Suntory Limited, Osaka, JP;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C12P / ; C12N / ; C12N / ; C07K / ;
U.S. Cl.
CPC ...
435 691 ; 4352523 ; 4353201 ; 43525233 ; 536 27 ; 514 12 ; 514869 ;
Abstract

Disclosed is a DNA fragment comprising a base sequence coding for a peptide occurring in human atrium cordis and having diuretic action or a precursor of the peptide, plasmids containing the DNA fragment, microorganisms transformed with the plasmid, and a process for production of the peptide using the transformant. Also disclosed is a new peptide consisting of 126 amino acids occurring in human atrium cordis and a precursor thereof. The peptide has notable diuretic action and hypotensive or antihypertensive actions.


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