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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5116943 B1

PDFFull Text
Date of Patent:
May. 26, 1992

Filed:

May. 10, 1988

Oxidation-resistant muteins of il-2 and other protein

Applicant:
Inventors:

Kirston E Koths, El Cerrito, CA (US);

Robert F Halenbeck, San Rafael, CA (US);

David F Mark, Plainsboro, NJ (US);

Danutee Nitecti, Berkeley, CA (US);

Assignee:

Cetus Corporation, Emeryville, CA (US);

Attorneys:

McGarrigle; Philip L.

Murphy; Lisabeth F.

Primary Examiner:

Garnette D Draper

Int. Cl.
CPC ...
C07K / ; A61K / ;
U.S. Cl.
CPC ...
530351 ; 530820 ; 530825 ; 435 6952 ; 435 6951 ; 435 695 ; 424 852 ; 424 851 ; 424 854 ; 424 855 ; 424 856 ; 424 857 ;
Abstract

A biologically active reference therapeutic protein is protected against oxidation by a method involving substituting a conservative amino acid for each methionyl residue susceptible to chloramine T or peroxide oxidation, wherein additional, non-susceptible methionyl residues are not so substituted. The oxidation-resistant mutein so produced is preferably a human mutein of interleukin-2 or interferon-.beta., and the conservative amino acid is most preferably alanine.

Find Patent Forward Citations

Koths, Kirston. (1992). Oxidation-resistant muteins of il-2 and other protein (U.S. Patent No. 5116943). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5116943

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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