The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 1992
Filed:
Sep. 07, 1989
Applicant:
Inventors:
Sachiko Yamada, Hachioji, JP;
Koichi Niimura, Sayama, JP;
Kenji Fukushima, Yokohama, JP;
Yuji Maeda, Nagareyama, JP;
Assignee:
Kureha Kagaku Kogyo Kabushiki Kaisha, Tokyo, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; C07C / ;
U.S. Cl.
CPC ...
424-11 ; 552653 ; 514167 ;
Abstract
The present invention discloses a novel, labelled vitamin D.sub.3 derivative in which hydrogen atoms on the skeleton portion, i.e. 6- and 19-positions, are substituted with a deuterium atom or a tritium atom, as well as a novel production process of the labelled vitamin D.sub.3 derivative carried out by way of sulfur dioxide addition reaction of a vitamin D.sub.3 derivative. The labelled portion of the novel vitamin D.sub.3 is resistant against in vivo metabolism and make a long period tracing of its pharmacodynamics in a living body possible.