The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 1992
Filed:
Sep. 25, 1990
Reijo Backstrom, Helsinki, FI;
Kalevi E Heinola, Jarvempaa, FI;
Erkki J Honkanen, Vantaa, FI;
Seppo K Kaakkola, Helsinki, FI;
Pekka J Kairisalo, Helsinki, FI;
Inge-Britt Y Linden, Helsinki, FI;
Pekka I Mannisto, Helsinki, FI;
Erkki A Nissinen, Espoo, FI;
Pentti Pohto, Helsinki, FI;
Aino K Pippuri, Espoo, FI;
Jarmo Pystynen, Espoo, FI;
Orion-yhtyma Oy, Espoo, FI;
Abstract
The invention concerns a method for the treatment of Parkinson's Disease. The method comprises administering a catechol-O-methyl-transferase inhibiting amount of a compound having the formula I ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, alkylcarbamoyl of 2 to 5 carbon atoms or alkylcarbonyl of 2 to 5 carbon atoms, X represents nitro or cyano and R.sub.3 represents ##STR2## wherein R.sub.4 represents cyano or alkylcarbonyl of 2 to 5 carbon atoms and R.sub.5 represents cyano; alkylcarbonyl of 2 to 5 carbon atoms; or carbamoyl which is unsubstituted or substituted with alkyl of 1 to 8 carbon atoms, or hydroxyalkyl of 1 to 8 carbon atoms or pharmaceutically acceptable salts or esters thereof; and a sufficient amount of levodopa to treat Parkinson's Disease. A peripheral decarboxylase inhibitor such as carbidopa or benzerazide is also preferably administered.