The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 05, 1992

Filed:

Aug. 17, 1990
Applicant:
Inventors:

Robert J Pryce, Faversham, GB;

John E Hawes, Sittingbourne, GB;

Sheetal Handa, Milton Regis, GB;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ;
U.S. Cl.
CPC ...
549450 ; 549448 ;
Abstract

A process for preparing a ketone of the general formula: ##STR1## in which R.sup.1 and R.sup.2 each independently represent a C.sub.1-6 alkyl or C.sub.6-12 aryl group, and R represents an alkyl, aryl, aralkyl, heterocyclic or carboxylic group, which process comprises reacting a carboxylic acid having the general formula I in which R represents a hydroxy group with a lithium compound to form the corresponding lithium salt of the carboxylic acid; reacting the lithium salt so-obtained with thionyl chloride to yield an acyl chloride having the general formula I in which R represents a chlorine atom; reacting the acyl chloride so-obtained with a secondary amine to yield an amide having general formula I in which R represents a secondary amino group; and reacting the amide so-obtained with an organometallic reagent to yield the ketone having general formula I.


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