The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 1992
Filed:
Feb. 21, 1991
Applicant:
Inventor:
Marcel E Nimni, Santa Monica, CA (US);
Assignee:
The University of Southern California, Los Angeles, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61F / ;
U.S. Cl.
CPC ...
623-2 ; 623 66 ;
Abstract
Processes are disclosed for improving the biostability of tissue implant devices. The processes comprise methods for treating harvested tissue with calcification inhibitor, tissue crosslinking reagent, and reagents capable of forming additional tissue reaction sites providing bioprosthetic devices having enhanced amounts of tissue bound calcification inhibitor. After long-term implantation, the treated tissue remains calcification free and exhibits a high degree of physical stability which minimizes the risk of mechanical failure.