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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5103029 B1

PDFFull Text
Date of Patent:
Apr. 07, 1992

Filed:

Apr. 06, 1989

Process for preparing 4-demethoxydaunomycinone

Applicant:
Inventors:

Walter Cabri, Limbiate, IT;

Silvia de Bernardinis, Milan, IT;

Franco Francalanci, Novara, IT;

Sergio Penco, Milan, IT;

Assignee:

Farmitalia Carlo Erba S.r.l., Milan, IT;

Attorney:

Oblon, Spivak, McClelland, Maier & Neustadt

Primary Examiner:

C Warren Ivy

Assistant Examiner:

Raymond Covington

Int. Cl.
CPC ...
C07C / ;
U.S. Cl.
CPC ...
552207 ; 552201 ;
Abstract

4-Demethoxy-daunomycinone I: ##STR1## the known aglycone of 4-demethoxy-daunorubicin, is prepared by protecting the 13-keto group of 4-demethyldaunomycinone, sulfonylating the 4-hydroxy group, reacting the sulfonylated compound, in an appropriate reducing environment, with a catalytic amount of a transition metal complex, preferably palladium or nickel with 1,3 diphenylphosphinopropane or 1,1'-bis (diphenylphosphino) ferrocene, and eliminating the 13-dioxolanyl group by treatment with trifluoroacetic acid.

Find Patent Forward Citations

Cabri, Walter. (1992). Process for preparing 4-demethoxydaunomycinone (U.S. Patent No. 5103029). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5103029

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